Safety of hormonal contraception among women with liver disease: an updated systematic review.

ABSTRACT:

Objectives

We sought to assess whether, among women with liver disease, there is an increased risk of adverse health effects with the use of hormonal contraception (HC).

Study design

We conducted a systematic review of six databases from database inception through December 13, 2022. We searched for articles that examined changes in liver lesions and acute and chronic liver disease with the use of HC or after discontinuation of HC. We assessed the risk of bias for each study and certainty of evidence for all outcomes.

Results

Thirteen articles met inclusion criteria, one with low risk of bias and the others with high risk of bias: three studies (four articles) were of women with focal nodular hyperplasia (FNH), five studies were of hepatocellular adenoma (HCA), and fou

SUBMITTER: Kapp N 

PROVIDER: S-EPMC12369956 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature