Evaluating the MT-CYB and MT-ATP6 variations in COVID-19 patients: A case-control study.

ABSTRACT: The complications and lingering effects of COVID-19 have caused a global health crisis, prompting intense investigations into the mechanism by which SARS-CoV-2 causes the disease. The majority of symptoms associated with this infectious disease are linked to mitochondrial dysfunction, and recent studies indicate that SARS-CoV-2 can impair host mitochondrial function. This study aims to investigate mutations in the MT-CYB and MT-ATP6 genes of mtDNA in COVID-19 patients and their association with disease outcomes. Out of 110 individuals enrolled, 30 were diagnosed with COVID-19, while the remaining 80 were healthy. Following DNA isolation from the blood samples, the MT-CYB and MT-ATP6 genes were amplified through PCR, purified, and sequenced using Sanger sequencing. In the MT-CYB gene, 9 dis

SUBMITTER: Sultana GNN 

PROVIDER: S-EPMC12370035 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature