Vitamin D enhances antiviral responses in dengue virus-infected macrophages by modulating early-response gene expression.

ABSTRACT: Dengue virus (DENV), the etiological agent of dengue fever, remains a global health concern, leading to severe illness and death in the absence of any definitive cure. Research has shown that vitamin D may reduce DENV replication in vitro and that dengue patients with low or deficient vitamin D levels are at higher risk of severe dengue. Studies indicate that viral replication is inhibited in human monocyte-derived macrophages (MDM) differentiated in the presence of vitamin D (D3MDM), suggesting that vitamin D may prevent DENV entry into host cells. However, despite these findings, the role of vitamin D in regulating the temporal expression patterns of genes as early, mid, and late transcriptional profile of DENV-infected macrophages remains unclear. Therefore, utilizing a kinetic transcri

SUBMITTER: Tamayo-Molina YS 

PROVIDER: S-EPMC12370076 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature