Factors associated with SARS-CoV-2 RNAemia development at COVID-19 diagnosis.

ABSTRACT: SARS-CoV-2 RNAemia at diagnosis is associated with mortality. The aims were to identify factors associated with the development of RNAemia. Multicenter COVID-19 cohort study was conducted between January 2020 and May 2023. Demographics, chronic underlying diseases, symptoms and signs, analytical and radiological variables, cytokines, and neutralizing antibodies were evaluated on admission. RNAemia was the primary endpoint. We included 1011 patients, 392 (38.8%) immunocompromised and 619 (61.2%) immunocompetent. RNAemia occurred in 49.7% and 18.7% (p < 0.001), respectively, being independently associated with 30-day all-cause mortality. In immunocompromised patients, factors independently associated with RNAemia were Alpha and Omicron VOC periods (OR: 1.95 [1.01-3.79]), pneumonia (OR: 1.96

SUBMITTER: Martin-Escolano J 

PROVIDER: S-EPMC12370080 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature