Phosphoproteomic profiling of feline mammary carcinoma: Insights into tumor grading and potential therapeutic targets.

ABSTRACT: Feline mammary carcinoma (FMC) is the most prevalent reproductive tumor in queens and is characterized by aggressive metastatic progression and short survival. Protein phosphorylation is a crucial process in cell regulation, with dysregulation linked to cancer progression, including human breast cancer. Although phosphoproteins have emerged as diagnostic and predictive markers in human breast cancer, knowledge remains limited on their role in FMC. In this study, the phosphoproteomic profiles of specimens for FMC grades 1 (n = 6), grade 2 (n = 11), grade 3 (n = 14), and normal controls (n = 6) were compared by phosphoprotein enrichment coupled with liquid chromatography-tandem mass spectrometry. Seventeen downregulated phosphoproteins were identified across all FMC grades, many of which hav

SUBMITTER: Aruvornlop P 

PROVIDER: S-EPMC12370146 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature