Understanding the alcohol harm paradox: A multivariable mendelian randomization approach.

ABSTRACT: The alcohol harm paradox, whereby low socioeconomic position (SEP) groups experience greater alcohol-related harms at a given level of alcohol consumption, is not yet fully understood. In observational studies, key drivers are correlated and share similar confounding structures. We used multivariable Mendelian randomization (MVMR) to estimate the direct causal effect of alcohol (drinks per week) and education (years of schooling) on multiple health outcomes, accounting for the effect of the other. Previously published genome-wide association summary (GWAS) statistics for drinks per week and years of schooling were used, and outcome summary statistics were generated from individual-level data from UK Biobank (N = 462,818). Inverse variance weighted analyses demonstrated evidence for direct

SUBMITTER: Sawyer G 

PROVIDER: S-EPMC12370186 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature