Predictors of Incident Benzodiazepine Co-prescription Among Patients Prescribed Long-term Opioids.

ABSTRACT:

Background

Opioid and benzodiazepine co-prescription is associated with overdose, particularly among patients prescribed long-term opioids.

Objectives

Identify predictors of incident benzodiazepine and opioid co-prescription using two separate and complementary large-scale patient cohorts.

Design

Two retrospective cohort studies: (a) statewide dataset based on California's prescription drug monitoring program (PDMP, 7/1/2016-12/1/2018) and (b) national sample of commercial and Medicare Advantage enrollees from the Optum Labs Data Warehouse (OLDW, 7/1/2016-12/1/2021).

Participants

Patients prescribed long-term opioids, with opioid coverage for ≥ 80% (≥ 144 days) of a 180-day baseline period absent baseline benzodiazepine or buprenorphine prescriptions. OLDW coho

SUBMITTER: Tseregounis IE 

PROVIDER: S-EPMC12370231 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature