Analyses of biomarkers for tremor using local field potentials recorded from deep brain stimulation electrodes in the thalamus.

ABSTRACT:

Background

Deep brain stimulation (DBS) of the ventral intermediate nucleus (VIM) of the thalamus (TH) is an effective therapy for suppressing tremor. One of the critical challenges to optimizing VIM-DBS therapy is the lack of robust neural biomarkers that correlate well with tremor.

Objective

To quantify biomarkers for tremor using intraoperative TH local field potential (LFP) recorded from DBS electrodes. Further, we used computational modeling to understand the biophysical basis of the recorded LFP signal.

Methods

We simultaneously recorded intraoperative TH LFP and tremor from the hand dorsum (32 participants) and during DBS at different frequencies (16 participants). Then, we simulated the effects of DBS and spatial distribution of tremor cells on calculated LFPs

SUBMITTER: Kumaravelu K 

PROVIDER: S-EPMC12370280 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature