Translocations can drive expression changes of multiple genes in regulons covering entire chromosome arms.

ABSTRACT: Chromosomal translocations have largely been implicated in tumor development. However, beyond the consequences of aberrant gene expression near the breakpoint, their effects remain underexplored. In this work, we characterize the interplay between translocations, chromatin organization and gene expression using mantle cell lymphoma (MCL) as a model. We show by in vitro genomic engineering and in MCL patient samples that translocations can drive transcriptional changes at entire chromosome arms affecting multiple genes in a regulon-like fashion. Moreover, we demonstrate a clear link between the translocation-induced transcriptional alterations and genome organization, with genes most susceptible to change expression forming pre-existing ultra-long-range interactions spanning 50 megabases. T

SUBMITTER: Oncins A 

PROVIDER: S-EPMC12370299 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature