Cytokine-Related Genes and Inflammatory Profiles as Potential Biomarkers in Major Depressive Disorder.

ABSTRACT:

Objective

Based on the neuroimmunological hypothesis of major depressive disorder (MDD), we analyzed the existing research to identify cytokine-related genes associated with MDD. Furthermore, we examined the cytokine alterations in patients with MDD as potential biomarkers for diagnosis and monitoring.

Methods

Differentially expressed genes (DEGs) related to MDD were identified using the GEO2R tool on public datasets, followed by functional enrichment analyses with Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathways. Protein-protein interaction (PPI) networks were constructed using Cytoscape to identify hub genes. Finally, blood samples from 20 patients with MDD and 10 healthy controls were analyzed using the Olink® Target 96 Inflammation panel with proximity

SUBMITTER: Oh H 

PROVIDER: S-EPMC12370437 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature