The Association Between Childhood Trauma and Selective Serotonin Reuptake Inhibitor Treatment Outcomes in Adult Patients With Major Depressive Disorder.

ABSTRACT:

Objective

The relationship between childhood trauma (CT) and the outcomes of selective serotonin reuptake inhibitor (SSRI) treatment for major depressive disorder (MDD) remains uncertain. The objective of this study is to investigate the overall association between CT and treatment outcomes in patients with MDD and the associations of different CT subtypes with the treatment outcomes of various MDD symptom dimensions.

Methods

A post hoc analysis of 285 adult patients with MDD from a multicenter, prospective study in China. Patients who completed the Childhood Trauma Questionnaire-Short Form (CTQ-SF) and 8-week SSRI treatment were included. Depressive symptoms were evaluated using the 17-item Hamilton Rating Scale for Depression (HRSD-17) at baseline and at 2, 4, and 8 weeks.

SUBMITTER: Deng Y 

PROVIDER: S-EPMC12370438 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature