A systematic review of omics discovery studies to identify pertinent metabolic pathways for locally advanced rectal cancer in response to neoadjuvant chemoradiotherapy.

ABSTRACT: Locally advanced rectal cancer (LARC) has variable responses to neoadjuvant therapy (NAT). Therefore, identifying changes in biological pathways involved when LARC is treated with NAT is crucial for developing treatments to improve clinical outcomes, as NAT is both variable and unpredictable. Although individual studies have attempted to discern how the response differs at a transcriptomic, proteomic and metabolomic level, there has not been a unifying systematic review discerning the key changes in metabolic pathways in this patient population. This systematic review aims to understand how metabolomics, proteomics and transcriptomics can demonstrate how the perturbed metabolic pathways of the NAT response in LARC can provide targets for further clinical research. Thirteen studies met the

SUBMITTER: Kler A 

PROVIDER: S-EPMC12370562 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature