The causal relationship between inflammatory cytokines and lung cancer: a two-sample bidirectional mendelian randomization study.

ABSTRACT:

Objective

The objective is to investigate the causal link between inflammatory cytokines and lung cancer through the application of a two-sample bidirectional Mendelian randomization (MR) approach.

Method

This study gathered data from genome-wide association studies (GWAS), focusing on 91 inflammatory cytokines associated with lung cancer. The investigation into the causal link between inflammatory cytokines and lung cancer was performed utilizing several methods, including the inverse variance weighted (IVW) approach, weighted median (WM) method, MR Egger regression, weighted mode, and simple mode. The IVW method served as the primary evaluative metric, while various sensitivity analyses were carried out to assess the heterogeneity and horizontal pleiotropy of the MR outcom

SUBMITTER: Zhao K 

PROVIDER: S-EPMC12370609 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature