Identification of RNA binding protein genes associated with colorectal cancer by bioinformatics analysis.

ABSTRACT: Colorectal cancer (CRC) is a prevalent malignant neoplasm on a global scale, with tumor heterogeneity driving therapeutic resistance and poor prognosis. RNA-binding proteins (RBPs), which are involved in regulating post-transcriptional processes, are becoming more recognized for their involvement in the advancement of cancer. This research conducted a thorough examination of the prognostic and functional significance of RBP-related gene sets (RBPGs) in CRC by utilizing transcriptomic data from the cancer genome atlas (TCGA). Differential expression analysis identified 406 RBPGs (268 upregulated, 138 downregulated) in CRC. Protein-protein interaction (PPI) network analysis revealed key modules involving 394 nodes, highlighting their functional interconnectivity. A prognostic model was const

SUBMITTER: He RC 

PROVIDER: S-EPMC12370611 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature