Translating metabolomic evidence gathered from an animal model to a real human scenario: the post-mortem interval issue.

ABSTRACT: Translating findings from animal models to human applications remains a fundamental challenge across scientific research, with unique implications for post-mortem metabolomics. This work is aimed at applying NMR metabolomics to human aqueous humour for post-mortem interval estimation, based on a previously studied ovine model. Quantitative metabolomic profiling of 21 aqueous humour samples collected during from 11 forensic autopsies, with post-mortem intervals between 225 and 1164 min has been performed by 1H NMR spectroscopy. Most of the identified metabolites in human aqueous humour samples are shared with those previously identified in ovine samples, showing qualitative similarities, while quantitative differences in metabolites such as lactate and glutamate are observed due to species-

SUBMITTER: Chighine A 

PROVIDER: S-EPMC12370792 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature