A secreted signature discriminates indolent from aggressive prostate tumors.

ABSTRACT: No non-invasive biomarkers are clinically available to distinguish aggressive prostate cancer (PCa) from the indolent PCa, as thus may lead the misdiagnose and overtreatment to the patients. This study aims to identify secreted proteins and assess their potentials to discriminate two PCa subtypes. Microarray assay on tissue specimens of the discovery cohort identified secreted genes associated with invasive PCa and macrophage polarization, and the results were validated in an independent cohort. As elevated expression of ΔC499 has been linked to metastatic PCa and poorer prognosis, the relationship of key secretory genes and ΔC499 was investigated. Their roles on macrophage polarization were studied in co-cultured cells, PCa mouse model and patient blood samples. Finally, a multi-gene secr

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12370796 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature