Gingipain inhibitors as an innovative therapy for periodontal and associated-systemic diseases: a systematic review.

ABSTRACT: Periodontal diseases (PDs) are prevalent chronic inflammatory conditions linked to the progression of systemic disorders. Gingipains, cysteine proteases produced by Porphyromonas gingivalis, are key virulence factors involved in PD pathogenesis and host-tissue degradation. Inhibiting these enzymes has emerged as a promising therapeutic approach.

Objective

This systematic review evaluates the potential of gingipain inhibitors in the management of PDs and related systemic conditions.

Methods

A systematic search was conducted across PubMed, Scopus, and Web of Science using the PICOS framework. Studies were evaluated based on their objectives, experimental models, inhibitor types, and outcomes.

Results

Seven preclinical studies met the inclusion criteria. No clinical studi

SUBMITTER: Pedrosa ME 

PROVIDER: S-EPMC12370816 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature