Multi-centre normative brain mapping of intracranial EEG lifespan patterns in the human brain.

ABSTRACT: Understanding healthy human brain function is crucial to identify and map pathological tissue within it. Whilst previous studies have mapped intracranial EEG (icEEG) from non-epileptogenic brain regions, they often neglect age and sex effects. Further, they are limited by small sample sizes due to the modality's invasive nature. This study substantially expands the subject pool compared to existing literature, to create a multi-centre, normative map of brain activity which considers the effects of age, sex and recording hospital. Using interictal icEEG recordings from [Formula: see text] subjects across 15 centres, we constructed a normative map of non-pathological brain activity by regressing age and sex on relative band power in five frequency bands. A linear mixed model was implemented

SUBMITTER: Woodhouse H 

PROVIDER: S-EPMC12370820 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature