Fzf1p regulates an inducible response to nitrosative stress in Saccharomyces cerevisiae.

ABSTRACT: The mechanisms by which microorganisms sense and detoxify nitric oxide (*NO) are of particular interest due to the central role this molecule plays in innate immunity. We investigated the genetic basis of inducible nitric oxide (*NO) detoxification in Saccharomyces cerevisiae by characterizing the genome-wide transcriptional response to exogenously supplied *NO. Exposure to the *NO-generating compound dipropylenetriamine NONOate resulted in both a general stress response as well as a specific response characterized by the induction of a small set of genes, including the yeast flavohemoglobin YHB1, SSU1, and three additional uncharacterized open reading frames. Transcriptional induction of SSU1, which encodes a putative sulfite transporter, has previously been shown to require the zinc fing

SUBMITTER: Sarver A 

PROVIDER: S-EPMC1237083 | biostudies-literature | 2005 Oct

REPOSITORIES: biostudies-literature