Longitudinal metabolic profiling of women using selective serotonin reuptake inhibitors during pregnancy.

ABSTRACT: Selective serotonin reuptake inhibitors (SSRIs) are the most prescribed antidepressants for pregnant women. While SSRIs are known to alter the circulating metabolic profile in non-pregnant individuals, the association between SSRIs and the changes in circulating metabolome during pregnancy remains unstudied. Pregnancy itself induces significant metabolic adjustments to meet the increased nutritional demands, and these maternal metabolic changes are crucial for the normal development and growth of the fetus. To study the impact of SSRI usage on circulating maternal metabolome during pregnancy. A targeted nuclear magnetic resonance (NMR) spectroscopy method was used to analyze maternal serum samples obtained from the first trimester of pregnancy and at the time of the delivery from both SSRI

SUBMITTER: Itkonen A 

PROVIDER: S-EPMC12370871 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature