Integrative Mendelian randomization and multi-omics analysis identifies anti-allergic drug targets associated with cardiovascular disease risk.

ABSTRACT: Cardiovascular diseases (CVDs) are major global health threats. This study explores links between anti-allergic drugs and CVD risk, providing valuable insights for clinical pharmacotherapy. Mendelian randomization (MR) analyses were performed on 139 eQTLs for anti-allergic drugs in coronary artery disease (CAD), heart failure (HF), myocardial infarction (MI), and atrial fibrillation (AF) cohorts, with validation in independent cohorts. Sensitivity analyses, transcriptomics analysis, enrichment analysis, and molecular docking were performed to evaluate the robustness of causality, potential pathways and binding affinity. Furthermore, the FAERS database evaluated the cardiovascular adverse events associated with prednisone in combination with cardiovascular drugs. Among the 11 anti-allergic

SUBMITTER: Lian H 

PROVIDER: S-EPMC12370938 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature