Integrated multi-omics analysis identifies lipid metabolism biomarkers in ONFH and reveals therapeutic potential of retinoic acid.

ABSTRACT: Osteonecrosis of the femoral head (ONFH) is a debilitating condition frequently associated with dysregulation in lipid metabolism. The objective of this study was to identify potential biomarkers for ONFH through various analytical methods and experimental verification, thereby providing a robust reference for disease treatment. Utilizing public datasets, differential analysis was conducted and integrated with weighted gene co-expression network analysis to pinpoint key genes. Subsequently, biomarkers related to lipid metabolism in ONFH were identified by combining machine learning techniques with receiver operating characteristic curves. Furthermore, based on these biomarkers, a nomogram model was developed for diagnostic prediction. Immune infiltration was assessed, and drug predictions

SUBMITTER: Wang C 

PROVIDER: S-EPMC12371116 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature