Multi-omics analysis revealed biomarkers for coronary atherosclerosis: Occurrence and development.

ABSTRACT: Coronary atherosclerosis (CA) is a leading cause of cardiovascular diseases with the high morbidity and mortality; however, the current diagnostic methods, primarily based on symptoms, signs, lab examination and imaging, are often inadequate for detecting subclinical or early-stage CA, costly, and inaccessible in many cases. The objective of this study was to discover sensitive and specific biomarkers for the diagnosis of CA severity. We enrolled 443 participants, including CA patients and healthy controls, from three independent cohorts: discovery, testing, and blinded validation. Multi-omics data integration during the discovery phase identified key features of atherosclerotic progression and potential biomarkers. Biomarker panels were refined using random forest models in the testing co

SUBMITTER: He M 

PROVIDER: S-EPMC12371206 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature