Phage-mediated horizontal transfer of <i>Salmonella enterica</i> virulence genes with regulatory feedback from the host.

ABSTRACT: Phage-mediated horizontal transfer of virulence genes can enhance the transmission and pathogenicity of Salmonella enterica (S. enterica), a process potentially regulated by its regulatory mechanisms. In this study, we explored the global dynamics of phage-mediated horizontal transfer in S. enterica and investigated the role of its regulatory mechanisms in transduction. A total of 5178 viral sequences encoding 12 S. enterica virulence genes were retrieved from the Integrated Microbial Genomes and Virome (IMG/VR) database, alongside 466,136 S. enterica genomes from EnteroBase. Virulence genes, including iacP (acyl carrier protein), mgtB (P-type Mg²⁺ transporter), misL (autotransporter porin), and fliC (flagellar filam

SUBMITTER: She T 

PROVIDER: S-EPMC12371270 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature