Dataset Information

Methicillin-Resistant Staphylococcus aureus Infection to a Stent Graft in the Superficial Femoral Artery.

ABSTRACT: Endovascular therapies for peripheral artery disease have become widespread, but the risk of device infection, though rare, must be considered. Prompt management is essential to preserve the patient's limb and life. A 79-year-old man presented with intermittent claudication and resting pain in his left leg and underwent multiple endovascular treatments targeting the lesion in the left superficial femoral artery. After treatment, he developed fever, swelling, and pain in his right thigh. Further evaluation revealed an infection of a previously implanted stent graft in the right superficial femoral artery, necessitating surgical removal of the graft. Stent graft infections, though uncommon, can have severe consequences. Prevention and early detection are critical, but diverse patient and lesion backgrounds often complicate this process. This case highlights the potential risks of infections in implanted devices for peripheral artery disease and underscores the importance of proper management.

SUBMITTER: Kimura M

PROVIDER: S-EPMC12371359 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature

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Methicillin-Resistant Staphylococcus aureus Infection to a Stent Graft in the Superficial Femoral Artery.

Kimura Mitsukuni M Suematsu Nobuhiro N Okadome Jun J Ito Hiroyuki H Kubota Toru T

JACC. Case reports 20250801 24

<h4>Background</h4>Endovascular therapies for peripheral artery disease have become widespread, but the risk of device infection, though rare, must be considered. Prompt management is essential to preserve the patient's limb and life.<h4>Case summary</h4>A 79-year-old man presented with intermittent claudication and resting pain in his left leg and underwent multiple endovascular treatments targeting the lesion in the left superficial femoral artery. After treatment, he developed fever, swelling ...[more]

PMID: 40846382

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Project description:Methicillin resistant Staphylococcus aureus (MRSA) infection is becoming refractory to existing antibiotic therapy owing to the inherent ability of S. aureus to develop rapid resistance and is considered a major threat to public health. We found that a natural isolate of Bacillus pumilus from the Columbia River Estuary produces a strong anti-MRSA compound, amicoumacin A. As amicoumacin A has been reported to exhibit anti-microbial, anti-inflammatory, and anti-ulcer activities, we sought to uncover its mechanism of action. Genome-wide transcriptome analysis of S. aureus COL in response to amicoumacin A showed alteration in the expression of genes involved in several cellular processes including cell envelope turnover, cross-membrane transport, virulence, metabolism, and general stress response. The most highly induced gene was lrgA, encoding an antiholin-like product, which has been shown to be induced in response to a collapse of membrane potential. In order to gain further insight into the mechanism of action of amicoumacin A, a whole genome comparison of wild-type COL and amicoumacin A-resistant mutants isolated by serial passage method was carried out. Single point mutations resulting in codon substitutions were uncovered in several distinct genes: ksgA, RNA dimethyltranferase; fusA, elongation factor G; dnaG, primase, ; lacD, tagatose 1,6-bisphosphate aldolase, ; and SACOL0611, encoding a putative glycosyl transferase gene. Based on these results, a candidate approach was undertaken to recreate the same amino acid substitution individually in FusA and KsgA, each of which resulted in two-fold resistance towards amicoumacin A. The fusA gene is known as the site for fusidic acid- resistant mutations; however the codon substitutions in EF-G that cause amicoumacin A resistance and fusidic acid resistance occur in separate domains and do not bring about cross resistance. Taken together, these results suggest that amicoumacin A might cause perturbation of the cell membrane and lead to energy dissipation. Decreased rates of cellular metabolism including protein synthesis and DNA replication in resistant strains might allow cells to compensate for membrane dysfunction and thus increase cell survivability.

Dataset Information

Methicillin-Resistant Staphylococcus aureus Infection to a Stent Graft in the Superficial Femoral Artery.

Publications

Methicillin-Resistant Staphylococcus aureus Infection to a Stent Graft in the Superficial Femoral Artery.

Similar Datasets

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