Fist-Palm Test May Identify Mild Cognitive Impairment and Freezing of Gait in Parkinson's Disease: A Machine Learning Approach.

ABSTRACT:

Background

Mild cognitive impairment (MCI) and freezing of gait (FOG) are two common symptoms in Parkinson's disease (PD).

Objectives

The objectives were to test the strength of association of fist-palm test (FiPaT), a nonverbal motor test, with both MCI and FOG in PD and investigate the predictive ability of FiPaT in the identification of PD patients with MCI or FOG.

Methods

We enrolled 74 PD patients: 47 of 74 patients had MCI (PD + MCI), 27 of 74 were cognitively unimpaired (PD-NC), 29 of 74 presented FOG (PD + FOG), and 45 of 74 were without FOG (PD-FOG). We performed univariate statistical analysis, including binary logistic regressions, to determine the variables that distinguish PD + MCI from PD-NC and PD + FOG from PD-FOG. We implemented machine learning algor

SUBMITTER: Cuoco S 

PROVIDER: S-EPMC12371445 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature