Rest-Activity Disturbances Correlate with Core Features in Dementia with Lewy Bodies.

ABSTRACT:

Background

Sleep-wake disturbances are a clinically important and poorly studied feature of dementia with Lewy bodies (DLB) due to the challenges of in-laboratory polysomnography in this population.

Objectives

To compare rest-activity rhythms in DLB, Parkinson's disease (PD), and age-matched controls using home-based wrist actigraphy and examine their relationship with core clinical DLB features.

Methods

Eleven DLB patients, 12 PD patients, and 11 age-matched controls underwent clinical assessment. Actigraphy data were obtained over 14 days and analyzed using nonparametric methods.

Results

DLB patients demonstrated higher rest-activity rhythm fragmentation (P = 0.002) than controls and lower circadian amplitude (P = 0.011) than both PD and controls. Instability

SUBMITTER: Anderson J 

PROVIDER: S-EPMC12371458 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature