Genetics Influences Telomere Length in Parkinson's Disease: A Study in Monozygotic Discordant Twins.

ABSTRACT:

Background

Parkinson's disease (PD) results from complex interactions among environmental, genetic, and aging factors. Telomeres, which ensure chromosome stability, naturally shorten with cell division, contributing to aging and cellular senescence. However, studies investigating telomere length (TL) in PD have produced inconsistent results.

Objective

This study aims to explore the relationship between TL and PD using a unique PD-discordant monozygotic twin design, which minimizes confounding factors such as age, gender, and genetic background. We also examined the impact of PD-related genetic mutations on TL.

Methods

We analyzed relative telomere length (RTL) in blood samples from 29 pairs of monozygotic twins discordant for PD. Data was stratified by disease duratio

SUBMITTER: Straniero L 

PROVIDER: S-EPMC12371635 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature