Distinct gray matter and metabolic characteristics in hypothalamic hamartoma network with different semiology.

ABSTRACT:

Objective

Hypothalamic hamartomas (HHs) are developmental malformations associated with focal epilepsy. We investigated the patterns of gray matter morphology and cerebral metabolism in individuals with HHs, with and without focal to bilateral tonic-clonic seizures (FBTCSs), aiming to clarify the accompanying network abnormalities.

Methods

We analyzed magnetic resonance imaging (MRI) and fluorodeoxyglucose positron emission tomography (PET) data from 59 patients with HHs (28 with FBTCSs, 31 without), as well as MRI data from 30 healthy controls (HCs) and PET data from 45 HCs. We assessed gray matter voxel-based morphometry and quantitative analysis of cerebral glucose uptake in HH patients and controls, with age, sex, and total intracranial volume as covariates, and drew cor

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12371636 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature