Neural Mechanisms of Object Location Memory in Huntington's Disease.

ABSTRACT:

Background

Object-location memory impairment in Huntington's disease (HD) occurs from premanifest period and declines as HD progresses, however, pathogenesis of object-location memory is unknown. The striatum and hippocampus are affected in HD, functionally interacting allowing intact object-location memory.

Objectives

The present study investigated if object location memory impairment in premanifest and manifest HD was associated with aberrations in effective connectivity between striatum and hippocampal formation.

Methods

Using dynamic causal modelling, we examined effective connectivity between the striatum and hippocampus and association with object-location memory in 35 HD participants (23 premanifest, 12 early manifest) and 32 controls.

Results

HD partici

SUBMITTER: Glikmann-Johnston Y 

PROVIDER: S-EPMC12371679 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature