Revealing the Impact of Mono(2-ethylhexyl) Phthalate (MEHP) on Prostate Cancer Based on Network Toxicology and Molecular Docking Approaches.

ABSTRACT: Mono(2-ethylhexyl) phthalate (MEHP) is a ubiquitous environmental contaminant and endocrine-disrupting chemical (EDC), identified as a potential carcinogen. Emerging studies have begun to elucidate the impact of MEHP on prostate cancer (PCa), yet its pathogenic effects and the underlying molecular mechanisms remain unclear. This study seeks to explore the molecular basis through which MEHP affects the onset and progression of PCa. Using network toxicology and bioinformatics, we identified MEHP-related pathogenic genes in PCa. An innovative predictive model was developed by employing multiple machine learning ensemble algorithms, and its performance was validated using the area under the receiver operating characteristic (ROC) curve. Furthermore, at the single-cell resolution, the role of k

SUBMITTER: Liang C 

PROVIDER: S-EPMC12371784 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature