The Proteome of African Spitting and Non-Spitting Cobra Venoms and Cytotoxicity Against Pancreatic Cancer Cells.

ABSTRACT: African cobra (Naja spp.) venom contains toxins dominated by proteins and peptides with inter- and intra-specific variations. There are several FDA-approved drugs from snake venom toxins from other regions, including South America and Asia. Profiling the proteomes of medically important African cobra venoms from different locations will aid in developing more effective anticancer agents. The venoms of spitting cobras (Naja pallida and Naja nigricincta woodi) and non-spitting cobras of the Uraeus subgenus (Naja anchietae, Naja annulifera, and Naja nivea) were fractionated by reverse phase-high performance liquid chromatography (RP-HPLC). Using label-free LC-MS/MS, the venom toxins were identified and grouped into families based on their relative abundance. Venom cytotoxicity of both crude a

SUBMITTER: Offor BC 

PROVIDER: S-EPMC12371851 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature