Regulation of EMT-MET and chemoresistance by the Lc3Cer-synthase B3GNT5.

ABSTRACT: Glycosphingolipids (GSL) are essential components of the plasma membrane where they are known to play key structural and functional roles and are known to influence molecular processes involved in cancer malignancy, including multi-drug chemoresistance, the epithelial to mesenchymal transition (EMT), and the activation or receptor tyrosine kinases (RTK). Thus, investigating and understanding how GSLs are regulated in cancer and the impact they have on malignancy have important therapeutic potential. In the GSL biosynthetic pathway, one critical regulator of two of the four major branches of GSLs is the gene product of B3GNT5, which produces the precursor for all GSLs in the lactoside and neolactoside series. Publicly available data was mined to determine the types and prevalence of genetic

SUBMITTER: Clark LE 

PROVIDER: S-EPMC12372232 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature