An explorative study on the interaction of cyclin-dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1/ANRIL) gene polymorphism with obesity on periodontitis among Norwegian adults.

ABSTRACT: Objective ANRIL is a pleiotropic gene with a strong link to periodontitis. ANRIL gene variant rs1537373 is associated with altered CDKN2B gene expression, which is linked to obesity. In this explorative, cross-sectional population-based study, we aimed to investigate the hypothesis that ANRIL (rs1537373) T>G may be associated with periodontitis through interactions, focusing on rs1537373×obesity interaction. Methods Genotyping for ANRIL (rs1537373), and clinical and periodontal examination were performed in 3554 participants (aged 40-93 years, 52% women) from the seventh survey of the Tromsø Study (2015-2016), Norway. We defined periodontitis stage based on radiographic bone loss (2018 AAP/EFP classification). Results The individual association between rs1537373 and periodontitis, as well

SUBMITTER: Petrenya N 

PROVIDER: S-EPMC12372528 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature