Does Ideal Blood Pressure Vary by Cognitive Domain? A UK Biobank Study.

ABSTRACT: High blood pressure (BP) is a risk factor for cognitive decline. Increasingly, studies have found the relationship to be nonlinear, with low BP also indicating higher risk. This UK Biobank study examines the nonlinear relationships between BP and cognitive function, including whether the relationships differ by cognitive domain. Systolic (SBP) and diastolic BP (DBP) were measured at baseline. Cognitive domains included fluid intelligence, attention, and reaction time, measured at baseline and over time. Nonlinear mixed-effects regression models, including natural spline terms for SBP and DBP, were used to assess the relationships. Additional models evaluated interactions with age, sex, and hypertension history/antihypertensive use. There were 439 301 (mean age = 56.3, SD = 8.1, 45.1% male)

SUBMITTER: Lennon MJ 

PROVIDER: S-EPMC12373150 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature