Comparison of the composition and antiplasmodial activity of Artemisia annua teas using an untargeted metabolomic approach.

ABSTRACT: The use of teas made from locally cultivated Artemisia annua to fight malaria in remote areas where access to care is difficult is a matter of debate. This study aimed at document differences in the composition of A. annua teas cultivated in Benin to be sold as antimalarial teas, and in France, and their impact on antiplasmodial activity. A. annua teas were prepared with plants from one location in south France and from ten different plantations in Benin. Artemisinin was quantified in herbal teas with a liquid chromatography system coupled to mass spectrometry and multiple reaction monitoring detection methods. The herbal teas were tested against chloroquine-sensitive 3D7 strain of Plasmodium falciparum using isotopic microtest to determine IC50 values and calculate the concentration of ar

SUBMITTER: Aubouy A 

PROVIDER: S-EPMC12373170 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature