Investigating the Trichosanthis Pericarpium - Trichosanthis Radix herbal pair's role in alleviating COPD through gut microbiota function, metabolomics analysis and cell validation experiment.

ABSTRACT: The herbal pair of Trichosanthis Pericarpium - Trichosanthis Radix (TP-TR) is derived from the classic prescription Bei-Mu-Gua-Lou-San in Yixue Xinwu, which is commonly used to treat lung heat and cough. Both originate from Trichosanthes kirilowii Maxim, a medicinal plant known for its effects to clear heat, dissolve phlegm, promote salivation, and relieve dryness. However, the compatibility, pharmacological synergy and gut-lung axis regulation mechanisms of TP-TR remain unclear. This study innovatively explores the therapeutic effects and underlying mechanisms of TP-TR in COPD through microbiome and amino acid metabolism. A COPD rat model was established to evaluate the efficacy of TP-TR. The gut microbiota was analyzed with 16S rRNA sequencing, while the metabolites in serum and lung wer

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC12373185 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature