Fetal programming through early weaning shapes the metabotype of Nelore heifers.

ABSTRACT: This study investigated the effects of fetal programming induced by early weaning (EW) of the previous calf on the serum metabotype of Nelore heifers. A 2 × 2 factorial design was employed, considering maternal category (multiparous vs. second-parity) and weaning strategy [EW vs. conventional weaning (CW)]. A total of 55 heifers were evaluated, including 25 born to cows subjected to EW (15 multiparous, 10 second-parity) and 30 born to cows subjected to CW (15 multiparous, 15 second-parity). Serum samples were collected from heifers at an average age of 14 months prior to the initiation pf the fixed-time artificial insemination (FTAI) protocol, and metabolomic profiling was conducted using ¹H-NMR spectroscopy. Data analysis was performed using R software and MetaboAnalyst 6.0. The effects o

SUBMITTER: Yaseen A 

PROVIDER: S-EPMC12373197 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature