Pattern recognition receptor-associated immuno-thrombotic transcript changes in platelets and leukocytes with COVID19.

ABSTRACT: Respiratory infections are characterized by an increased risk of thrombosis, likely involving platelet-leukocyte crosstalk via pattern recognition receptors (PRRs). Here we characterized COVID19-mediated changes in PRR levels and their associations with thrombotic/coagulation-related transcriptional programs across platelets and leukocytes and assessed their correlation with COVID19 outcomes. Amplicon RNAseq of platelets and leukocytes from COVID19 patients (n = 10) and non-infected donors (n = 15) showed distinct patterns of PRR-expression levels based on cell type. Platelets from non-infected donors expressed TLR9 > RIG-I> CGAS at the highest level while leukocytes expressed TLR4 > TLR8 > RIG-I. COVID19 resulted in increased levels of TLR9, RIG-I, CGAS, and TLR1 in platelets and decrease

SUBMITTER: Learnard H 

PROVIDER: S-EPMC12373281 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature