A software ecosystem for brain tractometry processing, analysis, and insight.

ABSTRACT: Tractometry uses diffusion-weighted magnetic resonance imaging (dMRI) to assess physical properties of brain connections. Here, we present an integrative ecosystem of software that performs all steps of tractometry: post-processing of dMRI data, delineation of major white matter pathways, and modeling of the tissue properties within them. This ecosystem also provides a set of interoperable and extensible tools for visualization and interpretation of the results that extract insights from these measurements. These include novel machine learning and statistical analysis methods adapted to the characteristic structure of tract-based data. We benchmark the performance of these statistical analysis methods in different datasets and analysis tasks, including hypothesis testing on group differenc

SUBMITTER: Kruper J 

PROVIDER: S-EPMC12373284 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature