Multiplex nodal modularity: A novel network metric for the regional analysis of amnestic mild cognitive impairment during a working memory binding task.

ABSTRACT: Modularity is a well-established concept for assessing community structures in various single and multi-layer networks, including those in biological and social domains. Brain networks are known to exhibit community structure at a variety of scales-local, meso, and global scale. However, modularity, while useful in describing mesoscale brain organization, is limited as a metric to a global scale describing the overall strength of community structure. This approach, while valuable, overlooks important variations in community structure at node level. To address this limitation, we extended modularity to individual nodes. This novel measure of nodal modularity (nQ) captures both mesoscale and local-scale changes in modularity. We hypothesized that nQ would illuminate granular changes in the b

SUBMITTER: Campbell-Cousins A 

PROVIDER: S-EPMC12373287 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature