IonBench: A benchmark of optimisation strategies for mathematical models of ion channel currents.

ABSTRACT: Ion channel models present many challenging optimisation problems. These include unidentifiable parameters, noisy data, unobserved states, and a combination of both fast and slow timescales. This can make it difficult to choose a suitable optimisation routine a priori. Nevertheless, many attempts have been made to design optimisation routines specifically for ion channel models, however, little work has been done to compare these optimisation approaches. We have developed ionBench, an open-source optimisation benchmarking framework, to evaluate and compare these approaches against a standard set of ion channel optimisation problems. We included implementations of thirty-four unique optimisation approaches that have been previously applied to ion channel models and evaluated them against th

SUBMITTER: Owen MJ 

PROVIDER: S-EPMC12373289 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature