Targeting STING to disrupt macrophage-mediated adhesion in encapsulating peritoneal sclerosis.

ABSTRACT: Encapsulating peritoneal sclerosis (EPS) is a life-threatening fibrotic condition characterized by severe abdominal adhesions, chronic inflammation, and significant morbidity. The lack of effective treatments for EPS stems from a limited understanding of its underlying mechanisms. In this study, we developed a modified mouse model of PD-induced EPS and investigated the role of the STING signaling pathway in disease progression. Our findings reveal that STING activation in peritoneal mesothelial cells significantly increases the secretion of the macrophage chemokine CCL2, leading to enhanced macrophage infiltration and the formation of pathological adhesions. Notably, pharmacological inhibition of STING using the inhibitor H151 effectively reduced macrophage infiltration and fibrosis, demon

SUBMITTER: Sun J 

PROVIDER: S-EPMC12373792 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature