Nucleolar proteomics identifies S100A16 as a key nucleolar protein driving breast cancer metastasis.

ABSTRACT: Metastasis is the leading cause of poor clinical outcomes in solid tumors; yet despite recent advances many of the driving factors of metastasis remain poorly understood. Tumor cells that successfully metastasize are subject to numerous stress points from intrinsic and extrinsic factors that the cell must overcome to survive and colonize a secondary site. The nucleolus, the site of ribosome biogenesis, serves as a central hub for sensing and responding to cellular stress and plays a crucial role in this process; furthermore, emerging evidence highlights the potential role of ribosome biogenesis in driving metastasis. To further elucidate the interplay between nucleolar function and metastasis, we performed a comprehensive analysis of nucleolar proteomes from primary and metastatic breast c

SUBMITTER: Metge BJ 

PROVIDER: S-EPMC12373912 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature