"In silico analysis of human TLR3 missense single nucleotide polymorphisms and their potential association with cancer".

ABSTRACT: Cervical cancer is a prevalent malignancy worldwide and represents a significant health burden for women. Toll-like receptors (TLRs) are crucial components of the innate immune system and play a vital role in recognizing pathogen-associated molecular patterns. Among the TLRs, TLR3 has been implicated in the defense against viral infections, including human papillomavirus (HPV), the primary etiological agent of cervical cancer. Missense single-nucleotide polymorphisms (SNPs) in the TLR3 gene can alter its protein structure and potentially influence its function, leading to variations in immune responses and disease susceptibility. This study aimed to investigate the impact of TLR3 missense SNPs on cervical cancer development through in silico methods. A comprehensive analysis was performed

SUBMITTER: Agarwal M 

PROVIDER: S-EPMC12373945 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature