Alzheimer's Disease Research Center Down Syndrome Cores: Experience from two sites.

ABSTRACT: Down syndrome (DS) is the most common genetic cause of Alzheimer's disease (AD). As individuals with DS live longer, the prevalence of AD-related dementia increases, underscoring a growing public health concern. Historically, research efforts have largely overlooked the early manifestations and neuropathological trajectory of AD in DS, limiting our understanding of how closely it mirrors or diverges from sporadic AD in the general population. The Alzheimer's Disease Research Center (ADRC) network, supported by the National Institute on Aging (NIA), plays a critical role in addressing this gap. This paper highlights the experiences of two ADRCs-University of California, Irvine (UCI) and University of Kansas Medical Center (KU) in developing dedicated research cores focused on aging and AD i

SUBMITTER: Ptomey L 

PROVIDER: S-EPMC12374163 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature