Genome-Wide Association Studies of Delay Discounting and Impulsive Personality Traits in Children From the Adolescent Behavior and Cognitive Development Study.

ABSTRACT: Impulsivity, often operationalized as delay discounting (DD) and as impulsive personality traits via the UPPS-P scales, is a key transdiagnostic construct across psychiatric disorders. Recent genome-wide association studies (GWAS) have studied the genetic basis of impulsivity in adults, but it remains unclear how similar the genetic architecture of DD is in children. The present study conducted GWAS of DD and impulsivity traits in 5548 children (ages 9-10 years old) of genetically inferred European ancestry from the Adolescent Brain Cognitive Development (ABCD) Study. Heritability estimates for DD (h2 = 0.20, S.E. = 0.10) and UPPS-P subscales (h2 = 0.08-0.11 S.E. = 0.05) were comparable to adult estimates. Genetic correlations between adult and child impulsivity were modest (rg = 0.28-0.46

SUBMITTER: Deng WQ 

PROVIDER: S-EPMC12374252 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature