Long-term cardiometabolic and bone health consequences of ketogenic diet in children with refractory epilepsy.

ABSTRACT: Ketogenic diet (KD) is a well-tolerated and efficacious therapy for refractory epilepsy (RE). While numerous mild short-term side effects have been reported, long-term cardiometabolic and bone heath consequences of KD need more advanced work-up and were not fully evaluated especially in children. So, we aimed to evaluate cardiac, vascular, metabolic, bone health and growth consequences in children with RE receiving KD for more than 2 years compared to those receiving antiepileptic drugs (AEDs ) without any dietary interference. Fifty-six children following KD for at least 2 years, 27 classic KD and 29 modified atkins diet (MAD), were recruited in addition to 40 children with RE maintained on multiple AEDs. Lipid profile values, atherogenic indices, serum selenium binding protein 1, and ant

SUBMITTER: Bahbah WA 

PROVIDER: S-EPMC12374288 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature