Dataset Information
Comprehensive behavioral phenotyping of male Septin 3-deficient mice reveals task-specific abnormalities.
Ontology highlight
ABSTRACT:
SUBMITTER: Ageta-Ishihara N
PROVIDER: S-EPMC12374300 | biostudies-literature | 2025 Aug
REPOSITORIES: biostudies-literature
Publications
Comprehensive behavioral phenotyping of male Septin 3-deficient mice reveals task-specific abnormalities.
Molecular brain 20250822 1
The septin cytoskeleton is recognized as the fourth component of the cytoskeleton. Septin 3 (SEPT3)/G-septin is a neuron-selective subunit of the septin family and is widely expressed in mature neurons. We previously demonstrated that SEPT3 regulates long-term potentiation (L-LTP)-dependent extension of smooth endoplasmic reticulum (sER) into dendritic spines of granule cells in the hippocampal dentate gyrus (DG), and that Sept3 knockout (Sept3−/−) mice exhibited impairments in DG-dependent spat ...[more]