Molecular epidemiology and genomic features of Bordetella pertussis in Tianjin, China, 2023.

ABSTRACT: Pertussis, a highly contagious respiratory disease caused by Bordetella pertussis (BP), poses challenges due to genomic variation that may contribute to its persistence in vaccinated populations and the development of antimicrobial resistance. In this study, we characterized 27 BP isolates collected from Tianjin, China in 2023, using whole-genome sequencing and multilocus genotyping (MGT) to explore their genomic diversity. For comparative analysis, we selected 165 international BP genomes to examine the genomic diversity and evolutionary traits of Tianjin strains within a global context. The results revealed that all 27 isolates belonged to ST2 (100.0%), with no distinct phylogenetic clustering observed. Furthermore, phylogenetic analysis integrating 165 global BP genomes indicated that t

SUBMITTER: Lu X 

PROVIDER: S-EPMC12374303 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature